TISANE CELERY AS A NON-MEDICAL THERAPY IN HYPERTENSION PATIENTS

  • Indrawati Indrawati STIKES Dian Husada Mojokerto
  • Yulianto Yulianto STIKES Dian Husada Mojokerto
Keywords: Hypertension, Non-medical Therapy, Tisane Celery

Abstract

Background: An increase in the number of people with hypertension in Indonesia will indirectly make the burden of health financing higher and a decrease in Indonesia's human resources itself. This is because hypertension experienced, can trigger the occurrence of other diseases and at the same time has the potential to cause disability and death in sufferers. One type of non-medical therapy that can be used to control blood pressure is to consume celery tisane. Objective: This study aims to identify the potential of celery as a non-medical therapy in patients with hypertension. Design: This research is a literature review. In this study the authors chose quantitative research articles with quasy experimental and case control designs. Data Sources (include search dates): The author uses Google Scholar, PubMed and OneSearch databases. In searching for these sources the author uses the keywords English and Indonesian. The keywords used were hypertension, effectiveness, effect, comparison and celery to find the appropriate literature. Review Methods: The author uses a systematic review method according to the PRISMA stages which include identification, screening, inclusion and feasibility of the article findings which are then analyzed. Articles that meet the criteria will be reviewed to record the potential of celery as a non-medical therapy for hypertension sufferers. Results: Celery contains flavonoids, saponins, tannins, essential oils, flavo-glucosides (apiin), apigenin, phytosterols, choline, lipases, pthalides, asparagine, bitter substances, vitamins (A, B and C) and alkaloids. Antihypertension in celery comes from apigenin which is contained in celery. Apigenin itself is the main flavonoid in celery, this compound can lower blood pressure through blocking Ca2+ channels (calcium antagonists). Based on the results of the explanation above, it can be concluded that celery leaves can be used as a non-medical therapy for people with hypertension. Conclusion: Celery leaves have been shown to have the potential to be developed and utilized as a non-medical therapy for hypertension sufferers. The chemical content of celery leaves has been proven to be effective in helping people with hypertension control their blood pressure.

References

Abd‐Elrazek, A. M., Ibrahim, S. R., & El‐dash, H. A. (2022). The ameliorative effect of Apium graveolens & curcumin against Non-alcoholic fatty liver disease induced by high fructose-high fat diet in rats. Future Journal of Pharmaceutical Sciences, 8(1), 1–11.

Ahmad, A., & Rahman, S. (2022). Inhibitory Effect of Celery Extract (Apium Gravolens Linn) On Blood Pressure Reduction in Hypertension Elderly in Iman Clinic. Buletin Farmatera, 7(2).

Azizah, N. C. N., Astuti, D., Fanani, Z., Karyati, S., & Kurnia, W. (2020). The Influence of Celery Juice Againts Blood Pressure Reduction in Hypertension. Journal of Physics: Conference Series, 1477(6), 62009.

Bokti, S. B. K., & Saputri, F. A. (2018). Artikel Review: Formulasi Dan Evaluasi Sediaan Gel Dari Ekstrak Seledri (Apium graveolens. Linn.) Sebagai Anti-Inflamasi. Farmaka, 16(1), 63–71.

Darsini, D. (2022). Pemberdayaan Masyarakat Dalam Kesehatan Melalui Pelatihan Pembuatan Simplisia Kering Untuk Mengendalikan Resiko Faktor Komorbid Covid-19. Jurnal Bhakti Civitas Akademika, 5(1), 10.

El-Dashlouty, M. S., Eleskafy, A. M., & Abd El-Monsef, M. (2020). Relative Effects Of Chicory, Sonchus As Well As Leek And Celery Varieties On Paracetamol Hepatopathy And Immunity Of Rats. Journal of Home Economics, 30(4).

Gupta, J., Gupta, R., & Mathur, K. (2019). Pharmacognostical, Pharmacological And Traditional Perspectives Of Apium Graveolens : An Ethnomedicinal Plant. Int. J. Life Sci. Pharma Res, 9(3), 38–47.

Hostetler, G., Riedl, K., Cardenas, H., Diosa‐Toro, M., Arango, D., Schwartz, S., & Doseff, A. I. (2012). Flavone deglycosylation increases their anti‐inflammatory activity and absorption. Molecular Nutrition & Food Research, 56(4), 558–569.

Illes, J. D. (2021). Blood pressure change after celery juice ingestion in a hypertensive elderly male. Journal of Chiropractic Medicine, 20(2), 90–94.

Kandarini, Y. (2016). Tatalaksana Farmakologi Terapi Hipertensi. Denpasar: FK Universitas Udayana.

Karim, A., Johnson, N., Akhtar, M., Mona, S., & Safdar, Z. (2021). Effect of Apium Graveolens (Celery) Seed Extract on Serum Uric Acid Level of Hyperuricemic Rats and its Comparison with Allopurinol. Journal of Shalamar Medical & Dental College-JSHMDC, 2(2), 85–91.

Kemenkes RI, K. K. R. I. (2018). Profil Kesehatan Indonesia 2018.

Kemenkes RI, K. K. R. I. (2019). Mencegah dan Mengontrol Hipertensi Agar Terhindar dari Kerusakan Organ Jantung, Otak dan Ginjal.

Khosrowpour, Z., Fahimi, S., Faizi, M., Shaaban, Z., Tansaz, M., & Sahranavard, S. (2022). Evaluation of Formulated Herbal Syrup (Containing Fennel, Anise, and Celery) on the Letrozole-Induced Polycystic Ovary Syndrome Model. Jundishapur Journal of Natural Pharmaceutical Products, In Press.

Khotimah, H., Diyantoro, D. W. I., & Sundari, A. S. (2020). Screening In Vitro Antimicrobial Activity of Celery (Apium graveolens) against Staphylococcus sp. Malays. J. Med. Health Sci, 16, 72–77.

Li, H., Chen, J., He, L., Zhu, H., Huang, Z., Zhu, M., Fan, L., Wu, L., Yu, L., & Zhu, W. (2022). Transcriptome Analyses Reveal the Role of Light in Releasing the Morphological Dormancy of Celery Seed by Integrating Plant Hormones, Sugar Metabolism and Endosperm Weakening. International Journal of Molecular Sciences, 23(17), 10140.

Li, P., Jia, J., Zhang, D., Xie, J., Xu, X., & Wei, D. (2014). In vitro and in vivo antioxidant activities of a flavonoid isolated from celery (Apium graveolens L. var. dulce). Food & Function, 5(1), 50–56.

Li, S., Li, L., Yan, H., Jiang, X., Hu, W., Han, N., & Wang, D. (2019). Anti gouty arthritis and anti hyperuricemia properties of celery seed extracts in rodent models. Molecular Medicine Reports, 20(5), 4623–4633.

Liu, T., Liu, F.-G., Xie, H.-Q., & Mu, Q. (2012). Phytopathogenic fungal inhibitors from celery seeds. Natural Product Communications, 7(7), 1934578X1200700721.

Mans, K., & Aburjai, T. (2019). Accessing the hypoglycemic effects of seed extract from celery (Apium graveolens) in alloxan-induced diabetic rats. J Pharmaceutical Res Int, 26, 1–10.

Mariyona, K. (2020). Penurunan Tekanan Darah Penderita Hipertensi dengan Pemberian Air Rebusan Seledri (Apium graveolens L). MIKIA: Mimbar Ilmiah Kesehatan Ibu Dan Anak (Maternal and Neonatal Health Journal), 1–6.

Moț, P.-R., Gurbină, D., Stoin, D., & Cozma, A. (2019). Biophysical and nutritional characterization of some natural fruit and vegetable juices. Journal of Agroalimentary Processes and Technologies, 25(4), 222–226.

Mustafa, T. I., Abdullah, Z. K., Mahmood, N. M. S., Gorony, S. M. A., Chato, K. B., & Shareef, R. M. M. (2019). Effects of Celery Seed Extracts on Some Haematological and Biochemical Parameters in Albino Rats Treated with Gentamicin. Kurdistan Journal of Applied Research, 120–127.

Natsir, H., Wahab, A. W., Budi, P., Arif, A. R., Arfah, R. A., Djakad, S. R., & Fajriani, N. (2019). Phytochemical and antioxidant analysis of methanol extract of moringa and celery leaves. Journal of Physics: Conference Series, 1341(3), 32023.

Nguyen Thu, H., Nguyen Van, P., Le Viet, H., Ngo Minh, K., & Le Thi, T. (2020). Prediction of the xanthine oxidase inhibitory activity of celery seed extract from ultraviolet–visible spectrum using machine learning algorithms. SN Applied Sciences, 2(10), 1–12.

Powanda, M. C., Whitehouse, M. W., & Rainsford, K. D. (2015). Celery seed and related extracts with antiarthritic, antiulcer, and antimicrobial activities. Novel Natural Products: Therapeutic Effects in Pain, Arthritis and Gastro-Intestinal Diseases, 133–153.

Rusdiana, T. (2018). Telaah Tanaman Seledri (Apium graveolens L.) sebagai sumber bahan alam berpotensi tinggi dalam upaya promotif kesehatan. Indonesia Natural Research Pharmaceutical Journal, 3(1), 1–8.

Shanmugalıngam, V., & Rajamanoharan, P. (2021). Antidiabetic green leafy vegetables currently sold in Trincomalee District in Sri Lanka.

Siantar, R. L., Simanjuntak, F. M., & Aritonang, T. R. (2021). Efectiveness of Celery (Apium Graveolens) on Hppertension in The Elderly. Science Midwifery, 9(2), 360–365.

Simamora, L., Pinem, S. B., & Fithri, N. (2021). Efektifitas Jus Seledri Terhadap Penurunan Tekanan Darah Pada Lansia Penderita Hipertensi Di Wilayah Kerja Puskesmas Simalingkar. Journal of Health (JoH), 8(2), 67–74.

Simamora, L., Sembiring, N. M. P. B., & Sinaga, A. (2022). The Effectiveness Of Celery Boiled Water On Lowering Blood Pressure In The Elderly With Hypertension In The Working Area Of The Simalingkar Public Health Center In 2020. International Journal of Midwifery Research, 2(1).

Sowbhagya, H. B. (2014). Chemistry, technology, and nutraceutical functions of celery (Apium graveolens L.): an overview. Critical Reviews in Food Science and Nutrition, 54(3), 389–398.

Tsi, D., Das, N. P., & Tan, B. K. H. (1995). Effects of aqueous celery (Apium graveolens) extract on lipid parameters of rats fed a high fat diet. Planta Medica, 61(01), 18–21.

Ud Din, Z., Shad, A. A., Bakht, J., Ullah, I., & Jan, S. (2015). In vitro antimicrobial, antioxidant activity and phytochemical screening of Apium graveolens. Pakistan Journal of Pharmaceutical Sciences, 28(5).

Wahyuni, F., Renowati, R., Habibah, U., Utari, M. D., & Desriva, N. (2022). Perbandingan Efektifitas Antihipertensi Daun Tanaman Herbal Menurunkan Tekanan Darah Pada Tikus Betina Induksi Hipertensi. Ensiklopediaku, 4(2), 79–84.

WHO, W. H. O. (2022). Hypertension. World Health Organisation, August, 2022. https://www.who.int/news-room/fact-sheets/detail/hypertension

Published
2023-04-26
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